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Urine uric acid excretion increased at hours 2, 4 and 6 on day 1. There was a significant change at hours 4 and 6 for losartan versus placebo (p 0.0021) and at 6 hours when evaluating hydrochlorothiazide and losartan combination versus hydrochlorothiazide alone (p 0.0021). There were no significant serum uric acid level increases at hours 2 Research Highlights: In an analysis of almost 3 million patients taking a single high blood pressure medication for the first time, angiotensin receptor blockers (ARBs) were as good as angiotensin-converting enzyme (ACE) inhibitors at preventing niva thyroid Losartan versus valsartan in the treatment of patients with mild to moderate essential hypertension: data from a multicenter, randomized, double-blind, 12-week trial Clin Ther. 2024 Aug;23(8):. doi: 10.1016/s (01). Losartan and valsartan are angiotensin receptor blockers (ARBs) that work by blocking angiotensin II that causes blood vessels to constrict. Both losartan and valsartan are used to treat high blood pressure (hypertension). Losartan (Cozaar) Valsartan (Diovan) Irbesartan (Avapro) Candesartan (Atacand) Azilsartan (Edarbi) Olmesartan (Benicar) Unlike ACE inhibitors, ARBs don t usually cause a cough. Otherwise, they have similar side effects to ACE inhibitors. That includes the effects on the kidneys.